Chrysophanic acid ( 6) in total yield of 40.4% was synthesized from 3-nitrophthalic acid by dehydration, Friedel-Crafts acylation, reduction, diazotization, hydrolysis and cyclization. 以3-硝基邻苯二甲酸为原料,经脱水、傅克酰基化、还原、重氮化、水解和环合反应合成了大黄酚(6),总收率40.4%。
Determination of Content of Emodin, Chrysophanol Chrysophanic Acid and Rhein by β-Cyclodextrin Single Molecular Micelle Fluorometry β-环糊精单分子胶束荧光法测定大黄素、大黄酚与大黄酸的含量
Effects of pH and azone on the transdermal absorption of chrysophanic acid by mouse skin were studied in vitro by Valian& Chien horizontal diffusion cell and UV spectrometry. 采用V-C扩散池及小鼠皮肤建立的透皮模型和紫外可见分光光度法,考察了不同pH值及其条件下氮酮(Azone)对大黄提取物中大黄酚透皮吸收的影响。